2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog 관련 제품 (2417):

Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-112581A
    5-Methoxyuridine-5'-triphosphate
    5-Methoxyuridine-5'-triphosphate is a monomeric raw material that can be used for nucleic acid synthesis.
    5-Methoxyuridine-5'-triphosphate
  • HY-178597
    DMTr-2'-O-TBDMS-8-azanebularine-3'-CE-phosphoramidite
    DMTr-2'-O-TBDMS-8-azanebularine-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-TBDMS-8-azanebularine-3'-CE-phosphoramidite
  • HY-178662
    5'-O-DMTr-3'-β-OH-2'-5-Me-dU(Boc)
    5'-O-DMTr-3'-β-OH-2'-5-Me-dU(Boc) is a monomeric raw material that can be used for nucleic acid synthesis.
    5'-O-DMTr-3'-β-OH-2'-5-Me-dU(Boc)
  • HY-W1121735
    DMTr-2'-O-TBDMS-5-F-rU-3'-CE-phosphoramidite
    DMTr-2'-O-TBDMS-5-F-rU-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-TBDMS-5-F-rU-3'-CE-phosphoramidite
  • HY-178548
    3'-O-Azidomethyl-ATP
    3'-O-Azidomethyl-ATP is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-O-Azidomethyl-ATP
  • HY-W439487
    7,9-Dimethylguanine
    7,9-Dimethylguanine is a modified nucleotide base that is a product of RNA degradation. The level of 7,9-Dimethylguanine in urine and serum can be used as a scoring indicator for the severity of alcoholic liver disease (ALD).
    7,9-Dimethylguanine
  • HY-171535
    LNA-UTP
    LNA-UTP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    LNA-UTP
  • HY-160042A
    AFP aptamer sodium scrambled negative control
    AFP aptamer sodium scrambled negative control is the sequence scrambled negative control of AFP aptamer sodium.
    AFP aptamer sodium scrambled negative control
  • HY-134382
    7-CH-dADP
    7-CH-dADP (7-Deaza-2'-deoxyadenosine-5'-O-diphosphate) is a dehydroxylated and deaminated derivative of the nucleotide ADP.
    7-CH-dADP
  • HY-W545104
    N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite
    N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite
  • HY-185481
    3'-O-Allyl-dGTP
    3'-O-Allyl-dGTP is a nucleotide analog that can be used for oligonucleotide synthesis.
    3'-O-Allyl-dGTP
  • HY-178648
    DMTr-2'-O-Me-rA(Bz)-3'-(D)-DPSE-phosphoramidite
    DMTr-2'-O-Me-rA(Bz)-3'-(D)-DPSE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-Me-rA(Bz)-3'-(D)-DPSE-phosphoramidite
  • HY-178601
    O6-Me-GTP
    O6-Me-GTP is a monomeric raw material that can be used for nucleic acid synthesis.
    O6-Me-GTP
  • HY-137648C
    Rp-2'-O-Me-GTPαS tetrasodium
    Rp-2'-O-Me-GTPαS tetrasodium is a GTP (HY-113225) analog with a modified 2'-OH group.
    Rp-2'-O-Me-GTPαS tetrasodium
  • HY-W048489
    DMT-2'-O-MOE-Tr
    DMT-2'-O-MOE-Tr (5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-thymidine) is a nucleoside analog containing a dimethoxytrityl (DMT) group, commonly used in the synthesis of nucleic acids.
    DMT-2'-O-MOE-Tr
  • HY-W128600
    3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine
    3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine (3',5'-TIPS-Uridine) is a monomeric raw material that can be used for nucleic acid synthesis.
    3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine
  • HY-150145
    Cy5-UTP
    Cy5-UTP is a fluorescently labeled ribonucleotide triphosphate that can be used as a substrate for terminal deoxynucleotidyl transferase (TdT). Cy5-UTP can be employed to label RNA probes generated in vitro (Ex/Em: 650/665 nm). Cy5-UTP can be applied in FISH, multi-color fluorescence analysis, especially in dual-color expression arrays that combine with Cy5-UTP.
    Cy5-UTP
  • HY-W751672
    2′-O-Methyl-5-hydromethylcytidine
    2′-O-Methyl-5-hydromethylcytidine (hm5Cm) is a 5-hydroxymethylcytidine (HY-152854) derivative. 2′-O-Methyl-5-hydromethylcytidine has also been detected in tRNA.
    2′-O-Methyl-5-hydromethylcytidine
  • HY-119499R
    6-Thioguanosine (Standard)
    6-Thioguanosine (Standard) is the analytical standard of 6-Thioguanosine. This product is intended for research and analytical applications. 6-Thioguanosine (6-Mercaptoguanosine), an active nucleoside, is an Azathioprine metabolite. 6-Thioguanosine has immunosuppressive effects.
    6-Thioguanosine (Standard)
  • HY-131806A
    3'-O-Ac-dTTP sodium
    3'-O-Ac-dTTP sodium is an acetylated derivative of nucleoside 5′-triphosphate.
    3'-O-Ac-dTTP sodium